Advances in atopic dermatitis in 2015

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• 作者：Takashi Nomura ; MD ; PhD^a ; ^b ; ^{tnomura@kuhp.kyoto-u.ac.jp} ; Kenji Kabashima ; MD ; PhD^a ; ^c ; ^d
• 关键词：Atopic dermatitis ; filaggrin ; biologics ; cytokines ; chemokines ; thymic stromal lymphopoietin ; chemoattractant receptor-homologous molecule expressed on TH2 cells ; petrolatum ; ultraviolet B ; sirtuin 1 ; aryl hydrocarbon receptor ; Janus kinase ; signal transducer and activator of transcription 3 ; extracellular signal-regulated kinase ; pathogenic effector TH2 ; TH1 ; TH2 ; TH17 ; TH22 ; transepidermal water loss ; adiposity ; JTE-052
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：138
• 期：6
• 页码：1548-1555
• 全文大小：720 K
• 卷排序：138

文摘

This review aims to highlight recently published articles on atopic dermatitis (AD). Updated are the insights into epidemiology, pathology, diagnostics, and therapy. Epidemiologic studies have revealed a positive correlation between AD and systemic conditions, such as rheumatoid arthritis, inflammatory bowel disease, and neonatal adiposity. Pathologic findings highlight the involvement of novel barrier factors (desmoplakin and claudin), novel immune cell subsets (pathogenic effector TH2 cells and group 2 innate lymphoid cells), and differential skewing of helper T cells (eg, TH17 dominance in Asians with AD). As diagnostics, noninvasive examinations of the transepidermal water loss of neonates, the density of epidermal Staphylococcus species, and the gut flora might prognosticate the onset of AD. As for therapy, various methods are proposed, including conventional (petrolatum and UV) and molecule-oriented regimens targeting Janus kinase, signal transducer and activator of transcription 3, extracellular signal-regulated kinase, sirtuin 1, or aryl hydrocarbon receptor.