Relating specific connexin co-expression ratio to connexon composition and gap junction function
详细信息 查看全文
- 作者：T. Desplantez ; 1 ; 2 ; thomas.desplantez@ihu-liryc.fr" class="auth_mail" title="E-mail the corresponding author ; K. Grikscheit2 ; 3 ; N.M. Thomas4 ; N.S. Peters ; N.J. Severs ; E. Dupont
- 关键词：RLE ; rat liver epithelial ; ind40 ; stable transfected cells for Cx40 ; ind45 ; stable transfected cells for Cx45 ; indGFP ; stable transfected cells for green fluorescent protein ; PonA ; ponasterone A ; LY ; Lucifer Yellow ; Cxs ; connexins ; Cx43 ; connexin 43 ; Cx45 ; connexin 45 ; Cx40 ; connexin 40 ; GJCs ; gap junction channels
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：part_PB
- 页码：195-202
- 全文大小：1507 K
文摘
- •
Cx40 and Cx45 are induced as a function of the dose of inducer.
- •
Heteromerisation is detectable between Cx40 and Cx43 but not between Cx45 and Cx43.
- •
Both expressions of Cx40 and Cx45 decrease Lucifer Yellow transfer.
- •
Electrical coupling is decreased by Cx45 induction.
- •
Electrical coupling is decreased by low levels of Cx40 expression and increased at high levels.