Crystallization and preliminary X-ray diffraction studies of a toxic phospholipase A₂ from the venom of Vipera ammodytes meridionalis complexed to a synthetic inhibitor

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• 作者：Georgieva ; Dessislava Nikolova ; Rypniewski ; Wojciech ; Perbandt ; Markus ; Jain ; Mahendra ; Genov ; Nicolay ; et. al.
• 关键词：Phospholipase A₂ ; Venom ; X-ray analysis ; PLA₂ ; phospholipase A₂
• 刊名：Biochimica et Biophysica Acta - Proteins and Proteomics
• 出版年：2003
• 出版时间：August 21, 2003
• 年：2003
• 卷：1650
• 期：1-2
• 页码：1-3
• 全文大小：86.4 K

文摘

A toxic phospholipase A₂ (PLA₂) is isolated from the neurotoxic complex Vipoxin, the major lethal component of the venom of Vipera ammodytes meridionalis. The enzyme is complexed to the synthetic inhibitor elaidoylamide and crystallized. The crystals belong to the space group P2₁2₁2₁, with unit cell dimensions a