Statistical procedures for the determination of linearity, detection limits and measurement uncertainty: A deeper look into SPE-LC-Orbitrap mass spectrometry of pharmaceuticals in wastewater
Lack of validation strategies that are adapted to multi-residue quantification. Matrix-dependent Orbitrap linearity: stronger deviations in solvent than in matrix. Novel method to estimate more realistically detection limits using natural isotopes. Equations to estimate measurement precision from basic validation parameters. Thoroughly validated quantitative method for pharmaceuticals in wastewater.