Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents
Design and synthesis of new alkylated and glycosylated triazoles. The use of X-ray single crystals and 2D NMR for determination of the selectivity. Testing the antiproliferative activity on HEPG-2 and MCF-7 cancer cell lines. Using the molecular docking simulation to predict the mode of action.