Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents

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• 作者：Ahmed T.A. Boraei^a ; ^{Ahmed_tawfeek83@yahoo.com} ; Mohamed S. Gomaa^b ; El Sayed H. El Ashry^c ; Axel Duerkop^d
• 关键词：Anticancer activity ; HEPG-2 ; MCF-7 ; 1 ; 2 ; 4-Triazolethiones ; Selectivity ; Alkylation
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：360-371
• 全文大小：2191 K
• 卷排序：125

文摘

Design and synthesis of new alkylated and glycosylated triazoles. The use of X-ray single crystals and 2D NMR for determination of the selectivity. Testing the antiproliferative activity on HEPG-2 and MCF-7 cancer cell lines. Using the molecular docking simulation to predict the mode of action.