In vitro lifespan and senescent behaviour of human periosteal derived stem cells
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- 作者：Giovanni Vozzia ; Guendalina Lucarinib ; Manuela Dicarlob ; Chiara Andreonia ; Eleonora Salvolinib ; Concetta Ferrettib ; Monica Mattioli-Belmonteb ; m.mattioli@univpm.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：MSCs ; mesenchymal stem cells ; BM-MSCs ; bone marrow mesenchymal stem cells ; AD-MSCs ; adipose tissue derived mesenchymal stem cells ; PDPCs ; periosteum derived progenitor cells ; NO ; nitric oxide ; SA-βgal ; senescence associated β-galactosidase ; Runx2 ; runt-related transcription factor 2 ; Bmp2 ; bone morphogenetic protein 2 ; RANKL ; receptor activator of nuclear factor kappa-B ligand ; OPG ; osteoprotegerin ; Sox2 ; sex-determining region Y (SRY)-Box2 ; Oct4 ; octamer binding-4 ; D-PBS ; Dulbecco's phosphate-b
- 刊名：Bone
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：1-12
- 全文大小：1473 K
文摘
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Periosteum contains multipotent periosteal derived progenitor cells (PDPCs).
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Replicative-senescent PDPCs share the same features of elderly-derived PDPCs.
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The in silico mathematical model suggests NO production as “replicative senescence index”.
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Later PDPC passages suitable to in vitro test tissue engineering strategies for elderly