USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15
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- 作者：Michol Giovanna Savio1 ; 2 ; 4 ; Nadine Wollscheid1 ; 4 ; Elena Cavallaro1 ; Veronica Algisi1 ; Pier Paolo Di Fiore1 ; 2 ; 3 ; Sara Sigismund1 ; Elena Maspero1 ; Simona Polo1 ; 2 ; simona.polo@ifom.eu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ubiquitin ; deubiquitinating enzymes ; USP9X ; EGFR ; Eps15
- 刊名：Current Biology
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：26
- 期：2
- 页码：173-183
- 全文大小：2868 K
文摘
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Fifteen DUBs have impact on EGFR fate
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USP9X regulates EGFR internalization and trafficking
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The endocytic protein Eps15 is a relevant target of USP9X
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Monoubiquitination of Eps15 is required for EGFR internalization