Deubiquitinating enzymes in skeletal muscle atrophy—An essential role for USP19

详细信息    查看全文

• 作者：Simon S. Wing ; ^{simon.wing@mcgill.ca" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Muscle wasting ; Ubiquitin ; Deubiquitinases ; Autophagy ; Deubiquitinating enzymes ; USP19 ; USP14 ; USP2
• 刊名：International Journal of Biochemistry and Cell Biology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：79
• 期：Complete
• 页码：462-468
• 全文大小：758 K

文摘

The ubiquitin proteasome system is well recognized to be involved in mediating muscle atrophy in response to diverse catabolic conditions. To date, almost all of the genes that have been implicated are ubiquitin ligases. Although ubiquitination is modulated also by deubiquitinating enzymes, the roles of these enzymes in muscle wasting remains largely unexplored. In this article, the potential roles of deubiquitinating enzymes in regulating muscle size are discussed. This is followed by a review of the roles described for USP19, the deubiquitinating enzyme that has been most studied in muscle wasting. This enzyme is upregulated in muscle in many catabolic conditions and its inactivation leads to protection from muscle loss induced by stimuli that are common in many illnesses causing cachexia. It can regulate both protein synthesis and protein degradation as well as myogenesis, thereby modulating the key processes that control muscle mass. Roles for other deubiquitinating enzymes remain possible and to be explored.