The emerging role of deubiquitination in nucleotide excision repair

详细信息    查看全文

• 作者：Ling Zhang ; Feng Gong ; ^{fgong@med.miami.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：UV ; ultraviolet ; NER ; nucleotide excision repair ; TC-NER ; transcription coupled NER ; GG-NER ; global genome NER ; XPC ; xeroderma pigmentosum complementation group C ; UV-DDB DUB ; deubiquitinating enzyme ; CS ; cockayne syndrome ; CSA ; cockayne syndrome protein A ; CSB ; cockayne syndrome protein B ; CPDs ; cyclobutane-pyrimidine dimers ; 6&ndash ; 4PPs ; 6&ndash ; 4 pyrimidine-pyrimidone photoproducts
• 刊名：DNA Repair
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：44
• 期：Complete
• 页码：118-122
• 全文大小：555 K

文摘

Nucleotide excision repair (NER) protects genome stability by eliminating DNA helix distorting lesions, such as those induced by UV radiation. The addition and removal of ubiquitin, namely, ubiquitination and deubiquitination, have recently been demonstrated as general mechanisms to regulate protein functions. Accumulating evidence shows that several NER factors are subjected to extensive regulation by ubiquitination and deubiquitination. Thus, the balance between E3 ligases and deubiquitinating enzyme activities can dynamically alter the ubiquitin landscape at DNA damage sites, thereby regulating NER efficiency. Current knowledge about XPC ubiquitination by different ubiquitin E3 ligases highlights the importance of ubiquitin linkage types in regulating XPC binding and release from damaged DNA. Here, we discuss the emerging roles of deubiquitinating enzymes and their ubiquitin linkage specificities in NER.