Kinetics and molecular docking of vasicine from Adhatoda vasica: An acetylcholinesterase inhibitor for Alzheimer's disease
详细信息 查看全文
- 作者：S.K. Alia ; A.R. Hameda ; b ; n1ragab2004@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; M.M. Soltana ; A.M. El-Halawanyc ; d ; U.M. Hegazye ; A.A. Husseinf
- 关键词：A.vasica ; Adhatoda vasica ; AChE ; acetyl cholinesterase enzyme ; Ach ; acetylcholine ; AD ; Alzheimer's disease ; ATCI ; acetylthiocholine iodide ; CDCL3 ; deuterated chloroform ; DCM ; dichloromethane ; IC50 ; concentration of sample that inhibits the enzyme activity by 50% compared to the enzyme activity using solvent control ; MeOH ; methanol ; NRC ; National Research Centre
- 刊名：South African Journal of Botany
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：104
- 期：Complete
- 页码：118-124
- 全文大小：1190 K
文摘
- •
Four known alkaloids were isolated from Adhatoda vasica.
- •
Vasicine was the most potent AChE inhibitor among the tested compounds.
- •
Vasicine was found to be a reversible competitive inhibitor of AChE.
- •
Docking study revealed similarity of vasicine to tacrine in binding to AChE.