Extraction, characterization and biological activity of a (1,3)(1,6)-β-d-glucan from the pathogenic oomycete Pythium insidiosum

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• 作者：Juliana S.M. Tondolo^a ; ^{jutondolo@yahoo.com.br} ; Pauline C. Ledur^a ; ^{pauline.ledur@gmail.com} ; É ; rico S. Loreto^a ; ^b ; ^{erico.loreto@gmail.com} ; Camila M. Verdi^a ; ^{milaverdi@hotmail.com} ; Paula E.R. Bitencourt^b ; ^{bitencourt.paula@yahoo.com.br} ; Francielli P.K. de Jesus^c ; Jean P. Rocha^a ; ^{jeanpaulvet@yahoo.com.br} ; Sydney H. Alves^b ; ^{sydneyalves.ufsm@gmail.com} ; Guilherme L. Sassaki^d ; ^{sassaki@ufpr.br} ; Janio M. Santurio^a ; ^{janio.santurio@gmail.com}
• 关键词：Acetone (PubChem CID ; 180) ; Chloroform (PubChem CID ; 6212) ; Deuterium oxide (PubChem CID ; 24602) ; Dimethyl sulfoxide (PubChem CID ; 679) ; Dipotassium phosphate (PubChem CID ; 180) ; Formic acid (PubChem CID ; 284) ; Isopropyl alcohol (PubChem CID ; 3776) ; Monopotassium phosphate (PubChem CID ; 516951) ; Thimerosal (PubChem CID ; 16684434) ; Trifluoroacetic acid (PubChem CID ; 66521741)
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：719-727
• 全文大小：2003 K
• 卷排序：157

文摘

A branched (1,3)(1,6)-β-d-glucan was extracted from Pythium insidiosum cell wall. (1,3)(1,6)-β-d-glucan significantly stimulated the lymphocyte proliferation. P. insidiosum β-d-glucan promoted proliferation and differentiation of Th17 cells. The (1,3)(1,6)-β-d-glucan would be expected to exploit as a new immunotherapy.