- 作者：Tanja G.M. Vrijkotte ; PhDa ; T.Vrijkotte@amc.uva.nl ; Sietske J. Algera ; MSca ; b ; Ingeborg A. Brouwer ; PhDc ; Manon van Eijsden ; PhDd ; Marcel B. Twickler ; MD ; PhDe ; f
- 关键词：ABCD ; Amsterdam Born Children and their Development ; BMI ; Body mass index ; BW ; Birth weight ; LGA ; Large for gestational age ; SGA ; Small for gestational age ; TC ; Total cholesterol ; TG ; Triglycerides ; YHC ; Youth Health Care Centers
- 刊名：The Journal of Pediatrics
- 出版年：2011
- 出版时间：November, 2011
- 年：2011
- 卷：159
- 期：5
- 页码：736-742.e1
- 全文大小：414 K
Objective
To investigate whether randomly sampled maternal total cholesterol (TC) and triglycerides (TG) levels during early pregnancy are associated with birth weight (BW) and postnatal growth.Study design
Data were derived from the prospective Amsterdam Born Children and their Development cohort study. Randomly sampled TC and TG levels were determined in early gestation (median, 13; IQR, 12-14 weeks). Outcome measures were BW SDS and weight-for-gestational age; postnatal outcome measures were SDS in weight, length, and body mass index during the first year of life (total n = 2502).
Results
The highest TG level was associated with a higher BW SDS (differences 0.20 ¡À 0.06 between highest and middle quintile; P = .002) and with a higher prevalence (13 % ) of an infant large for gestational age compared with middle quintile (9 % ; P = .04). Infants from mothers in the lowest TG quintile had lower SDS in weight, length, and body mass index until age 3 months, and displayed accelerated postnatal growth patterns. Maternal TC was not associated with BW or postnatal growth.
Conclusion
High maternal TG levels in the first term of pregnancy were associated with higher BWs and subsequently a higher occurrence of infants large for gestational age, whereas low TG levels were associated with accelerated postnatal growth.