Historical developments in children's deep brain stimulation

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• 作者：Laura Cif^a ; ^b ; ^c ; ^d ; ^e ; ^{a-cif@chu-montpellier.fr} ; Philippe Coubes^a ; ^b ; ^c ; ^d
• 关键词：Paediatrics ; Dystonia ; Deep brain stimulation ; Developments
• 刊名：European Journal of Paediatric Neurology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：109-117
• 全文大小：377 K
• 卷排序：21

文摘

Childhood onset dystonia is frequently progressive, with worsening towards generalization and consequent disability. GPi DBS is efficient in isolated dystonia, subcortical myoclonus, dystonic tremor and tics; STN and motor thalamic nuclei are under exploration. In acquired dystonia, neurometabolic and degenerative disorders, DBS role deserves exploration to confirm as an efficient and lasting therapy. The choice of neuromodulatory DBS parameters could influence not only the initial therapeutic outcome but also its maintenance over time. DBS opens a new window towards a better understanding of the physiology of different movement and psychiatric disorders.