Influence of maternal thyroid hormones during gestation on fetal brain development

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• 作者：N.K. Moog^a ; S. Entringer^a ; ^b ; ^c ; C. Heim^a ; ^d ; P.D. Wadhwa^b ; ^c ; ^e ; ^f ; ^g ; N. Kathmann^h ; C. Buss^a ; ^b ; ^c ; ^{claudia.buss@charite.de}
• 关键词：11β-HSD2 ; 11b-hydroxysteroid dehydrogenase type 2 ; ACTH ; adrenocorticotropic hormone ; ADHD ; attention-deficit hyperactivity disorder ; ASD ; autism spectrum disorder ; BDNF ; brain-derived neurotrophic factor ; CNS ; central nervous system ; CRH ; corticotropin-releasing hormone ; D ; deiodinase ; DG ; dentate gyrus ; fT3 ; free triiodothyronine ; fT4 ; free thyroxine ; GABA ; γ-aminobutyric acid ; GAD65 ; glutamic acid decarboxylase 65 ; GC ; glucocorticoid ; GH ; growth hormone ; hCG ; human chorionic gonadotropin ; HPA
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：342
• 期：Complete
• 页码：68-100
• 全文大小：987 K
• 卷排序：342

文摘

Thyroid hormones (THs) are crucial for key maturational processes during early brain development. Maternal TH deficiency during pregnancy may result in impaired offspring cognitive development. Gestational conditions related to stress may modulate maternal thyroid function.