High-throughput downstream process development for cell-based products using aqueous two-phase systems
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- 作者：Sarah Zimmermanna ; Sarah Gretzingera ; b ; Marie-Luise Schwaba ; c ; Christian Scheedera ; Philipp K. Zimmermanna ; Stefan A. Oelmeiera ; d ; Eric Gottwalde ; Are Bogsnesf ; Mattias Hanssong ; Arne Stabyh ; Jü ; rgen Hubbuch ; Dr.a ; juergen.hubbuch@kit.edu" class="auth_mail" title="E-mail the corresponding author (Prof.)
- 关键词：High throughput screening (HTS) ; Downstream processing of cell-based products ; Label-free cell separation ; Aqueous two-phase systems (ATPS) ; High-throughput flow cytometry
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：1464
- 期：Complete
- 页码：1-11
- 全文大小：1891 K
文摘
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Design of a HTS-platform for downstream process development of cell-based products.
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Enabling technology for translational research.
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Investigation of key parameters influencing cell partitioning and separability.
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Case-study with the differentiable cell line HL-60 shows excellent separability.