Abstract # 1827 Cilia, an organelle central to psychoneuroimmunology - A characterization through its interactome

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• 作者：M. Ganapathiraju ; S. Chaparala ; C. Lo
• 刊名：Brain, Behavior, and Immunity
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：57
• 期：supp_S
• 页码：e33-e34
• 全文大小：44 K

文摘

Cilia are organelles present on the surface of many eukaryotic cell types. Motile and non-motile (primary) cilia drive the movement of body-fluids such as cerebrospinal fluid and mucus and also serve several important functions, and are increasingly viewed as a hub for neuronal signaling and brain development. Many ciliopathies have neuronal defects. Cilia also influence interleukins and inflammatory cytokines; ciliary proteins have roles in immune synapse formation. In order to elucidate the molecular mechanisms by which ciliary proteins relate to various psychoneuroimmunological functions, we constructed and analysed the ciliary protein interactome. Novel interactions were predicted for by applying a computational model that we developed, called HiPPIP, and known interactions were assembled from public databases. Cilia interactome, consisting of 165 cilia proteins, 765 novel interactions and 1,011 known interactions, has a highly-significant overlap with neurodegenerative and neuropsychiatric disorders. Neuronal pathways such as dopamine-DARPP32 feedback in cAMP signaling, dopamine receptor signaling, axonal guidance signaling, synaptic long-term potentiation and the immunity related pathways such as IL-1 and IL-3 signaling, CD28 signaling in T helper cells, and NFkB signalling, are associated with it. There are 184 proteins that are targeted by 548 drugs of which 103 are nervous system drugs. Cilia interactome provides the intellectual framework for rational design of new treatments for ciliopathies as well as neuropsychiatric disorders and future systems biology studies focused on these fascinating organelles.