The SWI/SNF chromatin remodeling complex exerts both negative and positive control over LET-23/EGFR-dependent vulval induction in Caenorhabditis elegans
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- 作者：Stephane Flibottea ; sflibotte@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bo Ram Kimb ; boram.kim@mail.utoronto.ca" class="auth_mail" title="E-mail the corresponding author ; Emily Van de Laarb ; emily.vandelaar@uhnresearch.ca" class="auth_mail" title="E-mail the corresponding author ; Louise Brownc ; louise@lunenfeld.ca" class="auth_mail" title="E-mail the corresponding author ; Nadeem Moghalb ; nadeem.moghal@uhnresearch.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：EGFR ; SWI/SNF ; C. elegans ; Vulva ; LET-23 ; SMARCA4
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：415
- 期：1
- 页码：46-63
- 全文大小：10663 K
文摘
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SWI/SNF is required for normal epidermal patterning and vulval development.
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Weak reduction in SWI/SNF activity induces ectopic vulval tissue.
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Strong reduction in SWI/SNF activity prevents vulval induction.
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SWI/SNF promotes LET-23/EGFR expression in developing vulval cells.
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A missense mutation in the PTH domain of catalytic SWSN-4 is a gain-of-function.