Mechanistic insight into neurotoxicity induced by developmental insults

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• 作者：Christoffer Tamm ; Sandra Ceccatelli ; ^{sandra.ceccatelli@ki.se}
• 关键词：Neurotoxicity ; Neural stem cells ; Cell death and differentiation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：482
• 期：3
• 页码：408-418
• 全文大小：763 K
• 卷排序：482

文摘

The developing nervous system is highly sensitive to toxic insults. Neural stem cells are relevant models for mechanistic studies as well as for identifying heritable effects due to epigenetic changes. Depending on the dose, the outcome of exposure to neurotoxicants ranges from altered proliferation and differentiation to cell death. The elucidation of neurotoxicity mechanisms is relevant for understanding the etiopathogenesis of developmental and adult nervous system disorders.