Review on crosstalk and common mechanisms of endocrine disruptors: Scaffolding to improve PBPK/PD model of EDC mixture

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• 作者：Raju Prasad Sharma ; Marta Schuhmacher ; Vikas Kumar ; ^{vikas.kumar@urv.cat}
• 刊名：Environment International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：1-14
• 全文大小：1482 K
• 卷排序：99

文摘

EDCs' mechanism involves multiple targets interfering hormone synthesis, metabolism and their biological action. Toxicodynamic interactions like crosstalk and common mechanisms are very important for elucidating the mixture effect. Window of exposure plays an important role in assessing the risk for developmental and reproductive disorders. In silico risk prediction can be improved by integrating toxicodynamic interactions of EDCs.