Developmental Origins of Health and Disease in swine: implications for animal production and biomedical research

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• 作者：A. Gonzalez-Bulnes^a ; ^b ; ^{bulnes@inia.es" class="auth_mail" title="E-mail the corresponding author} ; S. Astiz^a ; C. Ovilo^c ; C.J. Lopez-Bote^d ; L. Torres-Rovira^a ; ^e ; A. Barbero^d ; M. Ayuso^d ; C. Garcia-Contreras^c ; M. Vazquez-Gomez^d
• 关键词：Conceptus ; Pregnancy ; Prenatal programming ; Swine
• 刊名：Theriogenology
• 出版年：2016
• 出版时间：1 July 2016
• 年：2016
• 卷：86
• 期：1
• 页码：110-119
• 全文大小：883 K

文摘

The concept of Developmental Origins of Health and Disease (DOHaD) addresses, from a large set of epidemiological evidences in human beings and translational studies in animal models, both the importance of genetic predisposition and the determinant role of maternal nutrition during pregnancy on adult morphomics and homeostasis. Compelling evidences suggest that both overnutrition and undernutrition may modify the intrauterine environment of the conceptus and may alter the expression of its genome and therefore its phenotype during prenatal and postnatal life. In fact, the DOHaD concept is an extreme shift in the vision of the factors conditioning adult phenotype and supposes a drastic change from a gene-centric perspective, only modified by lifestyle and nutritional strategies during juvenile development and adulthood, to a more holistic approach in which environmental, parental, and prenatal conditions are strongly determining postnatal development and homeostasis. The implications of DOHaD are profound in all the mammalian species and the present review summarizes current knowledge on causes and consequences of DOHaD in pigs, both for meat production and as a well-recognized model for biomedicine research.