Advancing non-invasive neuromodulation clinical trials in children: Lessons from perinatal stroke

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• 作者：Adam Kirton ^{adam.kirton@albertahealthservices.ca}
• 关键词：Neuroplasticity ; Developmental plasticity ; Brain stimulation ; Cerebral palsy ; Perinatal stroke ; Transcranial magnetic stimulation ; Transcranial direct current stimulation ; Clinical trials
• 刊名：European Journal of Paediatric Neurology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：75-103
• 全文大小：1903 K
• 卷排序：21

文摘

Non-invasive neuromodulation offers therapeutic potential that is now ready for translation into the developing brain. Responsible progress relies on adherence to fundamental principles of clinical trial design and execution. Perinatal stroke, a focal injury of defined timing in an otherwise healthy brain, is an ideal model of human developmental plasticity in which models of motor organization are well defined. The cortical targets identified represent opportunity for neuromodulation to improve motor function in children with hemiparetic cerebral palsy, the evidence for which is rapidly emerging.