There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes
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- 作者：Ryan A. Devenyi ; Eric A. Sobie ; eric.sobie@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP ; action potential ; APD50 ; action potential duration at 50% repolarization ; CaT ; Ca2 ; + transient ; CaTA ; Ca2 ; + transient amplitude ; LV ; left ventricle ; Ito ; transient outward current ; IKur ; ultra-rapidly rectifying current ; ICaL ; L-type Ca2 ; + current ; SERCA ; sarco/endoplasmic reticulum Ca2 ; + ATPase ; NCX ; Na+/Ca2 ; + exchanger ; PMCA ; plasma membrane Ca2 ; + ATPase ; NKA ; Na+/K+ ATPase ; RyR ; ryanodine receptor ; Kdecay ; decay rate of CaT ; Kdecay ; caff ; CaT decay rate in pre
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：38-48
- 全文大小：1573 K
文摘
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Sensitivity analysis was performed on a model of the rat left ventricular myocyte.
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Ito has greater impact on Ca2 + transients than SERCA in the epicardial model.
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This model prediction was qualitatively supported by experimental tests.
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The model was adjusted to better quantitatively match our experimental results.
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K+ currents also have major impact on Ca2 + transients in a human atrial model.