Normal lactate concentration range in the neonatal brain

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• 作者：Moyoko Tomiyasu^a ; ^b ; ^c ; ^{tomiyasu.moyoko@qst.go.jp" class="auth_mail" title="E-mail the corresponding author} ; Noriko Aida^a ; ^b ; ^{naida@kcmc.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun Shibasaki^d ; ^{jshibasaki@kcmc.jp" class="auth_mail" title="E-mail the corresponding author} ; Yasuhiko Tachibana^a ; ^b ; ^{tachibana.yasuhiko@qst.go.jp" class="auth_mail" title="E-mail the corresponding author} ; Mamiko Endo^d ; ^{mendo@chiba-u.jp" class="auth_mail" title="E-mail the corresponding author} ; Kumiko Nozawa^a ; ^b ; ^{knozawa@kcmc.jp" class="auth_mail" title="E-mail the corresponding author} ; Eiji Shimizu^c ; ^{eiji@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author} ; Hiroshi Tsuji^e ; ^{tsuji.hiroshi@qst.go.jp" class="auth_mail" title="E-mail the corresponding author} ; Takayuki Obata^a ; ^b ; ^{obata.takayuki@qst.go.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BG ; basal ganglia ; Cho ; free choline and choline-containing compounds ; Cr ; creatine and phosphorylcreatine ; CS ; centrum semiovale ; Glx ; glutamate and glutamine complex ; mIns ; myo-inositol ; MRS ; magnetic resonance spectroscopy ; NAA ; N-acetylaspartate and N-acetyl-aspartyl-glutamate ; PCA ; postconceptional age ; %SD ; percentage standard deviation ; SNR ; signal-to-noise ratio ; TE ; echo time ; TR ; repetition time ; VOI ; volumes of interest
• 刊名：Magnetic Resonance Imaging
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：34
• 期：9
• 页码：1269-1273
• 全文大小：361 K

文摘

Lactate peaks are occasionally observed during in vivo magnetic resonance spectroscopy (MRS) scans of the neonatal brain, even in healthy patients. The purpose of this study was to investigate the normal range of neonatal brain lactate concentration, as a definitive normal range would be clinically valuable.

Methods

Using a clinical 3T scanner (echo/repetition times, 30/5000 ms), single-voxel MRS data were obtained from the basal ganglia (BG) and centrum semiovale (CS) in 48 healthy neonates (postconceptional age (PCA), 30–43 weeks), nine infants (age, 1–12 months old), and 20 children (age, 4–15 years). Lactate concentrations were calculated using an MRS signal quantification program, LCModel. Correlations between regional lactate concentration and PCA (neonates), or age (all subjects) were investigated.

Results

Absolute lactate concentrations of the BG and CS were as follows: neonates, 0.77 mM (0–2.02) [median (range)] and 0.77 (0–1.42), respectively; infants, 0.38 (0–0.79) and 0.49 (0.17–1.17); and children, 0.17 (0–0.76) and 0.22 (0–0.80). Overall, subjects' lactate concentrations decreased significantly with age (Spearman: BG, n = 61, ρ = −0.38, p = 0.003; CS, n = 68, ρ = −0.57, p < 0.001). However, during the neonatal period no correlations were detected between lactate concentration in either region and PCA.

Conclusion

We determined normal ranges of neonatal lactate concentration, which may prove useful for diagnostic purposes. Further studies regarding changes in brain lactate concentration during development would help clarify the reasons for higher concentrations observed during the neonatal period, and contribute to improvements in diagnoses.