Moderate consumption of white and fortified wine is associated with reduced odds of diabetic retinopathy

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• 作者：Eva K. Fenwick^a ; ^{fenwicke@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Jing Xie^a ; Ryan Eyn Kidd Man^c ; Lyndell L. Lim^a ; Victoria M. Flood^b ; Robert P. Finger^a ; Tien Y. Wong^c ; ^d ; Ecosse L. Lamoureux^c ; ^d
• 关键词：Diabetic retinopathy ; Alcohol consumption ; Association ; White wine ; Fortified wine
• 刊名：Journal of Diabetes and its Complications
• 出版年：2015
• 出版时间：November-December 2015
• 年：2015
• 卷：29
• 期：8
• 页码：1009-1014
• 全文大小：381 K

文摘

To explore the association between alcohol consumption and the severity of diabetic retinopathy (DR).

Methods

In this cross-sectional study, patients with type 2 diabetes answered questions on consumption of low and full-strength beer, white wine/champagne, red wine, fortified wines, and spirits. Never, moderate and high consumption of each alcoholic beverage, and overall alcoholic beverage consumption, were defined as < 1, 1–14 and > 14 standard drinks/week, respectively. DR was categorized into none; non vision-threatening DR (VTDR) and VTDR. Multivariable logistic regression determined the associations between alcohol consumption and DR.

Results

Of the 395 participants (mean age ± SD [standard deviation] 65.9 ± 10.4 years; males = 253), 188 (47.6%) consumed alcohol and 235 (59.5%) had any DR. Compared to no alcohol consumption, moderate alcohol consumption (overall) was significantly associated with reduced odds of any DR (OR = 0.47, 95% CI [confidence interval] 0.26–0.85). Moderate consumption of white wine/champagne or fortified wine was also associated with reduced odds of any DR (OR = 0.48, 95% CI 0.25–0.91, and OR = 0.15, 95% CI 0.04–0.62, respectively). Similar results were observed for non-VTDR and VTDR.

Conclusions

The amount and type of alcohol are associated with risk of DR in patients with type 2 diabetes. A longitudinal study is needed to assess the protective effect of alcohol consumption and DR.