An ovine model of chronic stable heart failure

详细信息    查看全文

• 作者：Gerry Devlin ; Ken Matthews ; Geoff McCracken ; Selwyn Stuart ; Juliet Jensen ; John Conaglen ; John Bass
• 刊名：Journal of Cardiac Failure
• 出版年：2000
• 出版时间：June 2000
• 年：2000
• 卷：6
• 期：2
• 页码：140-143
• 全文大小：354 K

文摘

Background: Chronic stable large animal models of heart failure are difficult to establish. We report an ovine model of chronic stable heart failure achieved by a technique of repetitive myocardial infarctions (one of the most common causes of cardiac failure) with catheter-based techniques. Methods and Results: Ejection fraction (EF) was assessed by echocardiography. A perfusion catheter was positioned in either the left anterior descending or circumflex artery by using standard angioplasty techniques. Myocardial infarction was induced by a Gelfoam embolism via this catheter and was confirmed by electrocardiographic (ECG) changes and new segmental abnormalities. The procedure was repeated at 2 weekly intervals until the EF was less than 40 % . Target EF was achieved in 15 animals, with a mean of 3.4 embolizations (range 2 to 8). Baseline EF was 68 % , with a mean final EF of 33 % . This resulted in a 54 % reduction in EF (range 44 % to 68 % ) from baseline values. Two animals developed late symptomatic heart failure and died, whereas EF was stable at 3-month follow-up echocardiography in the remaining animals with no significant spontaneous improvement. Conclusion: Chronic stable heart failure can be established in sheep with catheter-based skills and a microembolization technique that causes repetitive myocardial infarctions.