Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice

详细信息    查看全文

• 作者：Augusto Schneider^a ; ^b ; ^{augusto.schneider@ufpel.edu.br} ; Scot J. Matkovich^c ; Tatiana Saccon^a ; Berta Victoria^b ; Lina Spinel^b ; Mitra Lavasani^d ; ^e ; Andrzej Bartke^f ; ^g ; Pawel Golusinski^b ; ^h ; ⁱ ; Michal M. Masternak^b ; ⁱ ; ^{michal.masternak@ucf.edu}
• 关键词：Ovarian aging ; GH ; IGF ; mRNA ; Transcriptome
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：328-336
• 全文大小：1669 K
• 卷排序：439

文摘

The ovarian reserve is three times larger in Ames dwarf (df/df) mice than normal (N) mice. More genes were differentially expressed during aging in N than df/df mice. Inflammatory response genes were up-regulated with aging in N mice. Inflammatory response genes were down-regulated in old df mice compared to N mice. DNA damage and repairing genes were down-regulated with aging in both genotypes.