LC/MS-based metabolomics strategy to assess the amelioration effects of ginseng total saponins on memory deficiency induced by simulated microgravity
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- 作者：Li Fenga ; Xiao-fei Yueb ; Yi-xi Chenc ; Xin-min Liua ; liuxinmin@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Li-sha Wanga ; Fang-rui Caoa ; Qiong Wangc ; Yong-hong Liaoa ; Rui-le Pana ; Qi Changa ; qchang@implad.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ach ; acetylcholine ; AD ; Alzheimer's disease ; Asn ; asparagine ; Asp ; aspartic acid ; BC ; behavioral research control group ; BH ; behavioral research HU group ; BHG ; behavioral research HU plus GTS treatment group ; CORT ; corticosterone ; DA ; dopamine ; DHBA ; dihydroxybenzoic acid ; E ; einephrine ; GABA ; gamma aminobutyric acid ; Glu ; glutamic acid ; GTS ; ginseng total saponins ; HPLC ; high performance liquid chromatography ; HU ; hindlimb unloading ; HVA ; homovanillic acid ; IDO ; indoleamine-2 ; 3-dioxygenase ; IS
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：329-338
- 全文大小：1761 K
文摘
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Ginseng total saponins (GTS) produce significant memory-improving effects.
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The memory-improving effect of GTS was studied by a LC/MS based metabolomics method.
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Metabolic changes of amino acids, neurotransmitters, and sphingolipids were noted.
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The study provide new insights into ginseng's memory-improving effects.