Drug-protein binding of Danhong injection and the potential influence of drug combination with aspirin: Insight by ultrafiltration LC-MS and molecular modeling

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• 作者：Junfeng Zhu ; Xiaojiao Yi ; Peng Huang ; Shuqing Chen ; Yongjiang Wu ; ^{yjwu@zju.edu.cn}
• 关键词：Drug-protein binding ; Danhong injection ; Aspirin ; Human serum albumin ; Ultrafiltration LC&ndash ; MS ; Molecular modeling
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：100-107
• 全文大小：1216 K
• 卷排序：134

文摘

Ultrafiltration LC–MS combined with molecular modeling was developed to investigate the drug-protein binding of DHI. Seven compounds in DHI were identified as HSA ligands. The influence of aspirin on the DHI-HSA binding was investigated by competitive binding assay.