Controlling molecular orientations of hydrogels in oil-drug@hydrogel particle delivery systems for pH-selective/sustained release and stabilization of bioactive drugs
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- 作者：Ji Eun Songa ; Sora Lima ; Do-Hoon Kimb ; dhkim777@amorepacific.com" class="auth_mail" title="E-mail the corresponding author ; Eun Chul Choa ; enjoe@hanyang.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oil&ndash ; drug@hydrogel shell particles ; Molecular orientation and crystallization of hydrogel ; pH-selective and sustained drug releases ; Anti-denaturation
- 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：490
- 期：Complete
- 页码：49-58
- 全文大小：3190 K
文摘
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Oil–drug@hydrogel particles with regulated molecular orientation of hydrogels are developed.
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The particles increase the loading efficiencies of drugs to as high as 90%.
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The oriented shells provide the particles environmental-selective drug deliveries.
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The particles are also effective in anti-denaturation of unstable drugs.