Association of osteoglycin and FAM5C with bone turnover markers, bone mineral density, and vertebral fractures in postmenopausal women with type 2 diabetes mellitus

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• 作者：Ken-ichiro Tanaka^a ; ^{ken1nai@med.shimane-u.ac.jp} ; Ippei Kanazawa^a ; ^{ippei.k@med.shimane-u.ac.jp} ; Hiroshi Kaji^b ; ^{hkaji@med.kindai.ac.jp} ; Toshitsugu Sugimoto^a ; ^{sugimoto@med.shimane-u.ac.jp}
• 关键词：OGN ; osteoglycin ; FAM5C ; family with sequence similarity 5 ; member C ; T2DM ; type 2 diabetes mellitus ; BMD ; bone mineral density ; LS ; lumbar spine ; FN ; femoral neck ; NTx ; type I collagen cross-linked N-telopeptide ; BMI ; body mass index ; HbA1c ; hemoglobin A1c ; LBM ; lean body mass ; RSMI ; relative skeletal muscle mass index ; OR ; odds ratio
• 刊名：Bone
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：5-10
• 全文大小：247 K
• 卷排序：95

文摘

Previous in vitro studies showed that muscle-derived factors, OGN and FAM5C, regulate osteoblastic differentiation. This is the first clinical study to investigate the association of serum OGN and FAM5C with bone metabolism. Serum OGN was significantly and positively associated with the presence of vertebral fractures. Serum FAM5C wasn’t associated with bone turnover markers, bone mineral density, or vertebral fractures. OGN is an important myokine linking muscle to bone, and is associated with the risk of vertebral fractures.