Impairment of neurovascular coupling in Type 1 Diabetes Mellitus in rats is prevented by pancreatic islet transplantation and reversed by a semi-selective PKC inhibitor

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• 作者：Francesco Vetri^a ; ^{vetri@uic.edu} ; Meirigeng Qi^b ; ¹ ; Haoliang Xu^a ; ² ; Jose Oberholzer^b ; Chanannait Paisansathan^a
• 关键词：aCSF ; artificial cerebrospinal fluid ; BKCa ; large-conductance Ca2+-operated K+ channel ; DM ; diabetic ; ND ; non-diabetic ; NVC ; neurovascular coupling ; Kir ; K+ inward rectifier channel ; PKC ; protein kinase C ; SEPs ; somatosensory evoked potentials ; STZ ; streptozotocin ; TR ; transplanted rats
• 刊名：Brain Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1655
• 期：Complete
• 页码：48-54
• 全文大小：561 K
• 卷排序：1655

文摘

Neurovascular coupling was impaired in diabetic vs either non-diabetic (ND) or pancreatic islet transplanted-rats (TR). Pial arteriolar dilations to KCl and NS1619 were suppressed in diabetic rats, but not in ND or TR animals. These responses were completely restored by the acute application of a PKC inhibitor, GF109203X. Diabetes-associated chronic impairment of neurovascular coupling may be reversed by a PKC inhibitor. Diabetes-associated chronic impairment of neurovascular coupling may be prevented via pancreatic islet transplantation.