Roles of specific lipid species in the cell and their molecular mechanism
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- 作者：Tomohiro Kimura ; William Jennings ; Richard M. Epand ; epand@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acc ; acetyl-CoA carboxylase ; ASM ; acid sphingomyelinase ; ATP ; adenosine triphosphate ; ATPase ; adenosine triphosphatase ; ATX ; autotaxin ; BMP ; bis(monoacylglycero)phosphate ; CDP ; cytidine diphosphate ; CL ; cardiolipin ; CNS ; central nervous system ; COPI ; coat protein I ; DAG ; diacylglycerol ; ER ; endoplasmic reticulum ; FRET ; fluorescence resonance energy transfer ; GPCR ; G protein coupled receptor ; Hsp ; heat shock protein ; IP3 ; inositol trisphosphate ; LHC II ; light harvesting complex II ; LPA ; lysophosp
- 刊名：Progress in Lipid Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：75-92
- 全文大小：1747 K
文摘
Thousands of different molecular species of lipids are present within a single cell, being involved in modulating the basic processes of life. The vast number of different lipid species can be organized into a number of different lipid classes, which may be defined as a group of lipids with a common chemical structure, such as the headgroup, apart from the nature of the hydrocarbon chains. Each lipid class has unique biological roles. In some cases, a relatively small change in the headgroup chemical structure can result in a drastic change in function. Such phenomena are well documented, and largely understood in terms of specific interactions with proteins. In contrast, there are observations that the entire structural specificity of a lipid molecule, including the hydrocarbon chains, is required for biological activity through specific interactions with membrane proteins. Understanding of these phenomena represents a fundamental change in our thinking of the functions of lipids in biology. There are an increasing number of diverse examples of roles for specific lipids in cellular processes including: Signal transduction; trafficking; morphological changes; cell division. We are gaining knowledge and understanding of the underlying molecular mechanisms. They are of growing importance in both basic and applied sciences.