Incremental diagnostic value of combined quantitative and qualitative parameters of magnetocardiography to detect coronary artery disease

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• 作者：Eun-Seok Shin^a ; ¹ ; Yat-Yin Lam^b ; ¹ ; Ae-Young Her^c ; ¹ ; Johannes Brachmann^d ; ¹ ; Friedrich Jung^e ; ¹ ; Jai-Wun Park^d ; ¹ ; ^{jai-wunpark@t-online.de}
• 关键词：Magnetocardiography ; Coronary artery disease ; Myocardial ischemia ; ST-segment fluctuation score ; Non-dipole phenomenon
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：948-952
• 全文大小：1332 K
• 卷排序：228

文摘

Magnetocardiography (MCG) has been proposed as a non-invasive and functional technique with high accuracy for diagnosis of myocardial ischemia. This study sought to investigate the incremental diagnostic value of combined quantitative and qualitative parameters of MCG to detect coronary artery disease (CAD).MethodsNinety six patients with suspected CAD who underwent coronary angiography were enrolled in the analysis to test the diagnostic accuracy of 2 MCG parameters (a quantitative parameter of the percent change of ST-segment fluctuation score and a qualitative parameter of non-dipole phenomenon).ResultsThe best cut-off value for the percent change of ST-segment fluctuation score was − 51.0%. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 78.1, 73.9, 82.0, 79.1, and 77.4, in the percent change of ST-segment fluctuation score and 86.5, 84.8, 88.0, 86.7, and 86.3 in non-dipole phenomenon. The area under the curve of receiver-operating characteristics was 0.79 for the percent change of ST-segment fluctuation score and 0.86 for non-dipole phenomenon (p < 0.001). However, the incorporation of non-dipole phenomenon into a model with the percent change of ST-segment fluctuation score significantly improved C-statistics, indicating the enhancement of diagnostic performance in the detection of significant CAD (0.790 to 0.930; p < 0.001).ConclusionsQualitative assessment of non-dipole phenomenon has a better diagnostic value than the quantitative parameter of percent change of ST-segment fluctuation score in the detection of significant CAD. Furthermore, this study found that the incorporation of non-dipole phenomenon into the percent change of ST-segment fluctuation score significantly improved the diagnostic performance of CAD detection.