Early detection of Toxoplasma gondii infection by using a interferon gamma release assay: A review

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• 作者：Shima Mahmoudi^a ; ^b ; Setareh Mamishi^a ; ^c ; Xun Suo^d ; ^e ; ^f ; Hossein Keshavarz^b ; ^g ; ^{hkeshavarz@tums.ac.ir}
• 关键词：Interferon-gamma release assay ; Toxoplasma gondii ; Diagnostic method
• 刊名：Experimental Parasitology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：172
• 期：Complete
• 页码：39-43
• 全文大小：274 K
• 卷排序：172

文摘

Interferon-gamma release assay (IGRA) was introduced as an in vitro test detecting T. gondii infection. Few studies have investigated the potential role of cell immunity in diagnosis of toxoplasmosis. IGRA accurately distinguished infected from uninfected individuals after in vitro stimulatoion with T. gondii antigens, even during the first days of life. IGRA is an easy-operation and low-cost method to measure cell mediated immunity against T. gondii. These results underline the importance of evaluating cellular immunity for early diagnosis of toxoplasmosis. ELISA-based IGRA holds the potential to become a useful diagnostic tool for early detection of T. gondii.