Regulation by chronic treatment with cabergoline of dopamine D1 and D2 receptor levels and their expression in the striatum of Parkinsonian-monkeys
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- 作者：Goulet ; Martin ; Grondin ; Richard ; Morissette ; Marc ; Maltais ; Sté ; phane ; Falardeau ; Pierre ; et. al.
- 关键词：binding autoradiography ; cabergoline ; D1 and D2 receptors ; in situ hybridization ; MPTP-monkeys ; striatum ; bovine serum albumine (BSA) ; complementary deoxyribonucleic acid (cDNA) ; 3 ; 3'-diaminobenzidine hydrochloride (DAB) ; diethyl pyrocarbonate (DEPC) ; deo
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2000
- 出版时间：May, 2000
- 年：2000
- 卷：24
- 期：4
- 页码：607-617
- 全文大小：532 K
文摘
Chronic treatment for one month with the long-acting dopamine D2-like agonist cabergoline (0.25 mg/kg s.c. every 48 hours), had despite partial tolerance, sustained antiparkinsonian activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonian monkeys (Macaca fascicularis).