A novel approach for targeted delivery to motoneurons using cholera toxin-B modified protocells
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- 作者：Maria A. Gonzalez Porrasa ; Paul N. Durfeec ; d ; Ashley M. Gregorya ; Gary C. Siecka ; b ; C. Jeffrey Brinkerc ; d ; e ; Carlos B. Mantilla ; M.D. ; Ph.D.a ; b ; mantilla.carlos@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuromuscular junction ; Nanotechnology ; Nanoparticles ; Motoneurons ; Drug delivery system ; Diaphragm ; Phrenic nerve ; Cholera toxin B ; Mesoporous silica nanoparticles
- 刊名：Journal of Neuroscience Methods
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：273
- 期：Complete
- 页码：160-174
- 全文大小：4549 K
文摘
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Cholera toxin-B (CTB) modified protocells provide a novel delivery method to target motoneurons.
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CTB-protocells display uptake by presynaptic axon terminals at neuromuscular junctions.
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CTB-protocells showed greater motoneuron uptake compared to unmodified protocells.
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CTB-protocells constitute a promising delivery vehicle for therapy in motoneuron diseases.