Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers
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- 作者：Loren J. Martin&lowast ; ; &dagger ; ; &Dagger ; ; lj.martin@utoronto.ca" class="auth_mail" title="E-mail the corresponding author ; Marjo H. Piltonen&dagger ; ; § ; ; Josee Gauthier¶ ; ; Marino Convertino‖ ; Erinn L. Acland&lowast ; ; &dagger ; ; &Dagger ; ; Nikolay V. Dokholyan‖ ; Jeffrey S. Mogil&lowast ; ; &dagger ; ; Luda Diatchenko&dagger ; ; § ; ; ¶ ; ; William Maixner¶ ;
- 关键词：Pain ; propranolol ; bupranolol ; β-adrenergic receptors ; antinociception
- 刊名：The Journal of Pain
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：12
- 页码：1321-1333
- 全文大小：1359 K
文摘
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Enantiomers of propranolol and bupranolol were compared for antinociception.
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S-Bupranolol is a superior antinoceptive agent on mouse models of persistent pain.
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S-Bupranolol exhibited fewer side effects than propranolol or associated enantiomers.
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S-Bupranolol produced a unique blockade of β3-adrenergic receptors.