A single MCR-ALS model for drug analysis in different formulations: Application on diazepam commercial preparations

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• 作者：Michele De Luca ; ^{michele.deluca@unical.it} ; Giuseppina Ioele ; Claudia Spatari ; Gaetano Ragno
• 关键词：Diazepam ; Multivariate curve resolution ; Partial least squares regression ; UV spectrophotometry ; Pharmaceutical analysis ; HPLC
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：346-351
• 全文大小：674 K
• 卷排序：134

文摘

MCR-ALS modelling was used to quantify diazepam in 30 commercial liquid formulations. MCR calibration was run on the UV–vis data of the commercial DZP samples. This model was optimized by appropriate selection of the most useful wavelengths. The predictive performance of the MCR model was compared with PLSR.