Chemistry and biological activity of azoprenylated secondary metabolites

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• 作者：Salvatore Genovese ; Massimo Curini ; Francesco Epifano
• 关键词：Alkaloids ; Biological activity ; Biosynthesis ; Chemical synthesis ; Microbial secondary metabolites ; Prenylazo secondary metabolites ; Rutaceae
• 刊名：Phytochemistry
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：70
• 期：9
• 页码：1082-1091
• 全文大小：1270 K

文摘

N-Prenyl secondary metabolites (isopentenylazo-, geranylazo-, farnesylazo- and their biosynthetic derivatives) represent a family of extremely rare natural products. Only in recent years have these alkaloids been recognized as interesting and valuable biologically active secondary metabolites. To date about 35 alkaloids have been isolated from plants mainly belonging to the Rutaceae family, and from fungi, bacteria, and/or obtained by chemical synthesis. These metabolites comprise anthranilic acid derivatives, diazepinones, and indole, and xanthine alkaloids. Many of the isolated prenylazo secondary metabolites and their semisynthetic derivatives are shown to exert valuable in vitro and in vivo anti-cancer, anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal effects. The aim of this comprehensive review is to examine the different types of prenylazo natural products from a chemical, phytochemical and biological perspective.