An efficient synthesis of pyrido-imidazodiazepinediones

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• 作者：Dominique P. Arama ; Vincent Lisowski ; Eliana Scarlata ; Pierre Fulcrand ; Ludovic T. Maillard ; Jean Martinez ; Nicolas Masurier ; ^{nicolas.masurier@univ-montp1.fr}
• 关键词：Diazepinones ; Friedel&ndash ; Crafts acylation ; Imidazo[1 ; 2-a]pyridine ; Polyfused heterocycles ; Urea derivatives
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：13 March, 2013
• 年：2013
• 卷：54
• 期：11
• 页码：1364-1367
• 全文大小：1311 K

文摘

We herein report the synthesis of a series of 12 optically pure 3,4-dihydro-1H-pyrido-[1¡ä,2¡ä:1,2]-imidazo[4,5-d][1,3]diazepine-2,5-diones, which form a new family of azaheterocycle-fused [1,3]diazepines. The key step of the synthesis consists in a selective C-acylation of 2-amino-imidazo[1,2-a]pyridine by various natural amino-acids, followed by an intracarbonylation reaction.