A series of 1,3-benzothiazoles and 4,5,6,7-tetrahydro-1,3-benzothiazoles were synthesized.
Several 1,3-benzothiazole derivatives showed a myorelaxant activity higher than diazoxide.
Their myorelaxant activity was explained, at least in part, by the opening of KATP channels.
Some 1,3-benzothiazole derivatives also provoked a marked inhibition of insulin secretion.