Diazoxide prevents reactive oxygen species and mitochondrial damage, leading to anti-hypertrophic effects

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• 作者：Aline M. Lucas^a ; Francisco R. Caldas^a ; Amanda P. da Silva^a ; Maximiano M. Ventura^a ; Iago M. Leite^a ; Ana B. Filgueiras^a ; Claú ; dio G.L. Silva^a ; Alicia J. Kowaltowski^b ; Heberty T. Facundo^a ; ^{heberty.facundo@ufca.edu.br}
• 关键词：Mitochondria ; Hypertrophy ; Oxidative stress ; Free radicals ; Calcium
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：261
• 期：Complete
• 页码：50-55
• 全文大小：399 K
• 卷排序：261

文摘

DZX protects against pathological cardiac hypertrophy. DZX enhances glutathione peroxidase activity and decrease H2O2 production. DZX avoids the opening of the mitochondrial permeability transition pore during cardiac hypertrophy.