Synthesis and biological activities of some new dibenzopyranones and dibenzopyrans: search for potential oestrogen receptor agonists and antagonists
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- 作者：Pandey ; Jaya ; Jha ; Ashok K. ; Hajela ; K.
- 关键词：Dibenzopyranones ; Dibenzopyrans ; Oestrogen receptor ; Agonists ; Antagonists
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2004
- 出版时间：May 1, 2004
- 年：2004
- 卷：12
- 期：9
- 页码：2239-2249
- 全文大小：355 K
文摘
Continuing our search for newer oestrogen agonists or antagonists and extending our work on the exploration of benzopyran related compounds, some new tricyclic molecules bridged between the active molecules of 3,4-diaryl chroman and 2,3-diaryl benzopyrans have been synthesised. Structural modifications at different positions with elements known to impart agonist or antagonist activities have been carried out to prepare the desired molecules. The target compounds were screened for their anti-osteoporotic (agonist) and anti-uterotrophic (antagonist) activities and were found to be moderately active.