Dihydrocaffeic acid, a major microbial metabolite of chlorogenic acids, shows similar protective effect than a yerba mate phenolic extract against oxidative stress in HepG2 cells
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- 作者：Gema Baeza ; Beatriz Sarriá ; Raquel Mateos ; Laura Bravo ; lbravo@ictan.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-CQA ; 5-caffeoylquinic acid ; 3 ; 5-DCQA ; 3 ; 5-dicaffeoylquinic acid ; CGAs ; chlorogenic acids ; CT ; control ; DCFH-DA ; dichlorofluorescein-2&prime ; 7&prime ; -diacetate ; DMSO ; dimethyl sulphoxide ; DNPH ; 2 ; 4-dinitrophenlyhydrazine ; DHCA ; dihydrocaffeic acid ; DHFA ; dihydroferulic acid ; FBS ; foetal bovine serum ; GPx ; glutathione peroxidase ; GR ; glutathione reductase ; GSH ; reduced glutathione ; LDH ; lactate dehydrogenase ; MDA ; malondialdehyde ; NADH ; nicotine adenine dinucleotide reduced ; NADPH ; nicotine aden
- 刊名：Food Research International
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：87
- 期：Complete
- 页码：25-33
- 全文大小：876 K
文摘
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YMPE and their major microbial metabolites are not cytotoxic to HepG2 cells.
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Direct treatment with YMPE, DHCA and DHFA decreases ROS generation in vitro.
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YMPE and its metabolite DHCA show similar protective effect against oxidative stress.
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DHCA could strengthen the effect of yerba mate at physiological concentrations.
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The methylated metabolite DHFA was less effective than DHCA.