5">YMPE and their major microbial metabolites are not cytotoxic to HepG2 cells.
Direct treatment with YMPE, DHCA and DHFA decreases ROS generation in vitro.
5">YMPE and its metabolite DHCA show similar protective effect against oxidative stress.
DHCA could strengthen the effect of yerba mate at physiological concentrations.
5">The methylated metabolite DHFA was less effective than DHCA.