Dichloroacetate alters Warburg metabolism, inhibits cell growth, and increases the X-ray sensitivity of human A549 and H1299 NSC lung cancer cells
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- 作者：Kah Tan Allena ; Helen Chin-Sinexb ; Thomas DeLucac ; Joseph R. Pomereningc ; Jeremy Shererb ; John B. Watkins IIIa ; John Foleya ; d ; e ; Jerry M. Jessepha ; Marc S. Mendoncab ; e ; f ; mmendonc@iupui.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DCA ; dichloroacetate ; PI ; propidium iodide ; NSCLC ; non-small-cell lung cancer ; SBRT ; stereotactic body radiation therapy
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：263-273
- 全文大小：894 K
文摘
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We treated human lung cancer cells A549 and H1299 with 50 mM dichloroacetate (DCA).
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DCA decreased lactate production and attenuated aerobic glycolysis.
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DCA slowed cell growth and altered cell cycle distribution.
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DCA significantly increased single and fractionated X-ray-induced cell killing.
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DCA inhibited X-ray-induced DNA double-strand break repair.