Targeting HIF-1α is a prerequisite for cell sensitivity to dichloroacetate (DCA) and metformin
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- 作者：Sung-Eun Honga ; 1 ; Hyeon-Ok Jinb ; 1 ; Hyun-Ah Kimc ; Min-Ki Seongc ; Eun-Kyu Kimd ; Sang-Kyu Yee ; Tae-Boo Choef ; Jin Kyung Leeb ; Jong-Il Kimg ; In-Chul Parka ; parkic@kcch.re.kr" class="auth_mail" title="E-mail the corresponding author ; Woo Chul Nohc ; nohwoo@kcch.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cancer metabolism ; Dichloroacetate ; Glycolytic enzymes ; HIF-1α ; Metformin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：8 January 2016
- 年：2016
- 卷：469
- 期：2
- 页码：164-170
- 全文大小：1068 K
文摘
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Combination of DCA and metformin synergistically enhances cancer cell death.
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HIF-1α mediates resistance to DCA/metformin induced cell death.
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Glycolytic enzymes are involved in HIF-1α induced DCA/metformin resistance.
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Targeting of HIF-1α may be an prerequisite for cancer metabolism targeted therapy.