Quantification of reactive carbonyl compounds in icodextrin-based peritoneal dialysis fluids by combined UHPLC-DAD and -MS/MS detection
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- 作者：Sabrina Gensberger-Reigla ; Jochen Huppertb ; Monika Pischetsriedera ; monika.pischetsrieder@fau.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-DG ; 3-deoxyglucosone ; 3-DGal ; 3-deoxygalactosone ; 3 ; 4-DDPS ; 3 ; 4-dideoxypentosone ; 3 ; 4-DGE ; 3 ; 4-dideoxyglucosone-3-ene ; 4-DG ; 4-deoxyglucosone ; 5-HMF ; 5-hydroxymethylfurfural ; DTPA ; diethylene triamine pentaacetic acid ; GDP ; glucose degradation product ; KET ; keto-enol tautomerization reactions ; MGO ; methylglyoxal ; MRM ; multiple reaction monitoring ; OPD ; o-phenylenediamine ; PD ; peritoneal dialysis ; pGDP ; polyglucose degradation product
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：132-138
- 全文大小：837 K
文摘
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Development and validation of a UHPLC-DAD-MS/MS method for pGDP analysis.
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Quantification of pGDPs in icodextrin-based peritoneal dialysis fluids.
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4-Deoxyglucosone is the main degradation product with concentrations up to 20 μM.
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In contrast to glucose-based products, 3-deoxygalactosone is predominant over 3-DG.
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Total pGDP contents in the commercial products were between 36.5 and 43.0 μM.