Influence of the nanoprecipitation conditions on the supramolecular structure of squalenoyled nanoparticles

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• 作者：Elise Lepeltier^a ; Claudie Bourgaux^a ; ^{claudie.bourgaux@u-psud.fr" class="auth_mail" title="E-mail the corresponding author} ; Heinz Amenitsch^b ; ^c ; Vé ; ronique Rosilio^a ; Sinda Lepetre-Mouelhi^a ; Fatima Zouhiri^a ; Didier Desma&euml ; le^a ; Patrick Couvreur^a
• 关键词：Adenosine ; Neuroprotective activity ; Nucleolipid ; Squalenoylation ; Nanoprecipitation ; Supramolecular structure ; High resolution synchrotron small-angle X-ray scattering (SAXS) ; Langmuir film
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：96
• 期：Complete
• 页码：89-95
• 全文大小：834 K

文摘

Hydrophobic organic compounds dissolved in a polar solvent can self-assemble into nanoparticles (NPs) upon nanoprecipitation into water. In the present study, we have investigated the structure of squalenacetyl-adenosine (SQAc-Ad) nanoparticles which were previously found to exhibit impressive neuroprotective activity. When obtained by nanoprecipitation of a SQAc-Ad ethanolic solution into water, two different supramolecular organizations of SQAc-Ad NPs were evidenced, depending on the water-to-ethanol volume ratio. It has been shown that a fraction of the solvent remained associated with the NPs, despite prolonged evaporation under reduced pressure after nanoprecipitation, and that this residual solvent dramatically affected their structure. This study points to the importance of being in the “Ouzo” region to minimize the amount and effect of residual solvent and to control the structure of NPs.