Secondary metabolites from Spirotropis longifolia (DC) Baill and their antifungal activity against human pathogenic fungi

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• 作者：Charlie Basset^a ; ^b ; Alice M.S. Rodrigues^a ; ^b ; Vé ; ronique Eparvier^c ; Maria R.R. Silva^d ; Norberto P. Lopes^e ; Daniel Sabatier^f ; Emile Fonty^f ; Laila S. Espindola^b ; ^{darvenne@unb.br} ; Didier Stien^a ; ^c ; ^{didier.stien@icsn.cnrs-gif.fr}
• 关键词：Spirotropis longifolia ; Leguminosae ; Prenylated pterocarpans ; Antifungal ; Cytotoxic ; Monodominant species
• 刊名：Phytochemistry
• 出版年：2012
• 出版时间：February, 2012
• 年：2012
• 卷：74
• 期：Complete
• 页码：166-172
• 全文大小：410 K

文摘

A phytochemical study of the ethyl acetate extract of the roots and adventitious roots of Spirotropis longifolia, a monodominant tree species of the Guianan rainforest, has allowed the isolation of three compounds: 2-hydroxy-8,9-methylenedioxy-2?2?dimethylpyrano-[5?6?4,3]-6a-prenyl-[6aS,11aS]-pterocarpan (spirotropin A), 2-hydroxy-8,9-methylenedioxy-2?2?dimethyl-3?4?dihydropyrano-[5?6?4,3]-6a-prenyl-[6aS,11aS]-pterocarpan (spirotropin B), and 5,7-dihydroxy-6,8-diprenyl--dimethylpyrano[: 3?4¡ä]-isoflavone (spirotropone). In addition, 10 known compounds, trans-oxyresveratrol, trans-resveratrol, piceatannol, daidzein, genistein, isoprunetin, lupeol, latifolol, gnetin D and gnetin E, were also isolated. These compounds were evaluated for their antifungal activity and their cytotoxicity, and their structures were established by 1D and 2D NMR, HRMS, CD and optical rotation measurements.